γGT- (Gamma glutamyl transferase)

Labkit

Carboxy substrate | Kinetic

Enquiry Now

Share on:

Gamma-glutamyltransferase (GGT) also known as gamma glutamyl transpeptidase (GGTP);is a well-established serum marker for alcohol-related liver disease. However, GGT's predictive utility applies well beyond liver disease: elevated GGT is linked to increased risk to a multitude of diseases and conditions, including cardiovascular disease, diabetes, metabolic syndrome (MetS), and all-cause mortality. The primary role of cellular GGT is to metabolize extracellular reduced glutathione (GSH), enabling precursor amino acids to be assimilated and re-utilized for synthesis of intracellular GSH. Serum GGT is therefore a marker of oxidative stress which leads to depletion of GSH.

 

Largest amounts of this enzyme are found in the kidney, with smaller accumulations in the liver and heart. It is a microsomal enzyme, but levels are frequently elevated in patients with liver disease characterized by stasis of bile flow. GGT is also elevated in patients with acute hepatocellular injury and in alcoholics while it is not elevated during pregnancy. A major value of this test is in confirmation of the significance of elevated levels of alkaline phosphatase. High levels of ALP activity in serum arise from hepatobiliary disease, bone disease, and  transient hyperphosphatasemia in children. The value of the γ-GT activity is often useful to differentiate, whether an elevation of ALP activity comes from the liver or the bones; high levels of both suggest liver origin.

Product Features:

  • IFCC method
  • Both ready to use reagents as well as lyophilized reagents for different customers’ choice.
  • Programmable on most of the fully automated biochemistry analyzers
  • Wide AMR: ranging between 2 and 300 iU/L and AMR =0 ~ 375 iU/L for kits 30220 and 30221.
  • A good correlation with other brands as well as DGKC-SCE method.
  • Longer working reagent stability ≥ 21 days at 2-8°C. / 3 days at R.T, making it ideal for semiautomatic instrument users.
  • Longer working reagent stability ≥ 21 days at 2-8°C. / 15 days at R.T, making it more suitable for semiautomatic instrument users with very less workload (prdt. code 30220 and 30221)

Product Code

Description

Pack Size

Standard/Control

 

 

30220

Generic Pack

20 x 2mL (Tablet format)

30221

Generic Pack

15 x 15mL (Tablet format)

30223/s

Generic Pack

R1=1 x 40mL   R2=1 x 10mL

30223

Generic Pack

R1=1 x 100mL   R2=1 x 25mL

30224

Generic Pack

R1=1 x 200mL   R2=1 x 50mL

SUBSCRIBE NOW

Get our updates always fast

Your personal data will always be safe