β2-Microglobulin

Labkit

Immunoturbidimetric method.

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Beta-2-microglobulin is a LMW protein (17 kDa), ubiquitously expressed, and a component of the MHC class I molecule. It is produced at a constant rate and freely filtered by the kidney. Similar to other LMW proteins, beta 2-microglobulin is completely reabsorbed by endocytosis on the proximal tubules and then completely catabolized within the tubular cell. The fractional urinary excretion of beta 2-microglobulin has been estimated at 0.03%. Levels are increased in the urine if there is direct functional impairment of the proximal tubular epithelial cells or an indirect compromise to proximal tubular function from protein overload (e.g., states of glomerular injury) and saturation of tubular transporters.

 

Levels of β2-microglobulin can be elevated in multiple myeloma and lymphoma, though in these cases primary amyloidosis (amyloid light chain) and secondary amyloidosis (amyloid associated protein) are more common. In lymphoma, β2-microglobulin levels usually correlate with the disease stage and tumor burden in patients with chronic lymphocytic leukaemia (CLL). For the diagnosis of multiple myeloma, the serum β2-microglobulin level is one of the prognostic factors incorporated into the International Staging System, though the levels cannotdistinguish between MGUS and smouldering myeloma. 

 

 

The serum β2-microglobulin level is elevated (>2.7 mg/L) in 75% of patients at the time of diagnosis. Patients with high values have inferior survival. The prognostic value of serum β2-microglobulin levels in myeloma is probably due to two factors:

 

  • High levels are associated with greater tumour burden.
  • High levels are also associated with renal failure, which carries an unfavourable prognosis.

Product features:

  • Immunoturbidimetric method.
  • For the estimation of both serum and urine levels of β2-microglobulin.
  • Ready to use reagents.
  • No prozone effect up to 100 mg/L in serum and 20 mg/L in urine.
  • Very good correlation with other commercially available reagents.
  • Calibrator is included in the pack.
  • The sensitivity of the assay and the target value of the calibrator have beenstandardized against the 1st International β2-microglobulin standard from WHO.
  • Average calibration stability =30 days under standard conditions.
  • AMR: Serum levels between 0.22 and 18 mg/L.
  • AMR: Urine levels between 0.04 and 3 mg/L.
  • For use on both semiautomatic analyzers and fully automated analyzers.
  • Controls-optional

Product Code

Description

Pack Size

Standard/Control

 

 

41050

R1 = 45 mL, R2 = 5 mL

Calibrator = 1 mL.

41055

R1 = 45 mL, R2 = 5 mL

Calibrator = 1 mL.

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