Immunoglobulin A (IgA)

Labkit

Immunoturbidimetry assay.

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In most of the higher vertebrates, the majority of IgA is synthesized by gastrointestinal lymphoid tissue, with smaller amounts synthesized at other mucosal sites such as the respiratory tract, salivary glands and reproductive tract. The total quantity of IgA synthesized in humans has been estimated to be 66 mg kg−1 day−1, of which approximately two-thirds is derived from mucosal lymphoid tissue. The relatively large amounts of IgA synthesized daily is concerned with mucosal defense; where the mucosal surfaces are constantly infected with organisms that are either commensal to the host or pathogenic. The bone marrow also provides an additional source of IgA, especially in humans.

IgA has two subclasses; IgA1 and IgA2. Mucosal antigen challenge provokes polymeric IgA (pIgA) production by plasma cells of the mucosa-associated lymphoid tissue. The pIgA is then transported across epithelium into mucosal fluids where it is released after coupling to secretory component as secretory IgA (sIgA), which is bone marrow derived and mostly monomeric IgA1.

IgA is generally increased in skin, pulmonary, kidney infections, IgA nephropathy (Berger’s disease), and hepatic cirrhosis. Increased monoclonal IgA concentrations may be found in multiple myeloma and other disturbances of plasmatic cells.

Product features.

  • Intended for the quantitative estimation of Ig A in serum or plasma.
  • Immunoturbidimetry assay.
  • Suitable for use on of semiautomatic analyzers.
  • Can be programmed on fully automated instruments – subject to analyser model.
  • Ready to use reagents
  • Optional calibrator with values traceable to CRM 470/RPPHS (IRMM).
  • 30 days calibration stability. The stability period may highly vary and is subjected to the working environment.
  • AMR up to 600mg/dL.
  • LOQ =1 mg/dL.
  • No prozone effect up to 2000mg/dL.
  • CE marked.

Product Code

Description

Pack Size

Standard/Control

 

 

42121LB

Generic Pack

50 mL

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