Serum proteins

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Serum proteins

Product Description

Cellulose acetate medium (CAE)

Available Options:

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Paraproteins (M-Proteins / monoclonal band) are the monoclonal immunoglobulins or immunoglobulin fractions that are produced by a clonal population of B-cell lineage cells. The presence of paraproteins in blood or urine may be related to  (1) monoclonal gammopathy of unknown significance (MGUS)- a benign condition characterized by abnormal serum paraproteins without any evidence of organ involvement, (2) multiple myeloma (MM)- a malignant condition characterized by either the possibility or presence of end-organ damage, such as renal failure secondary to cast nephropathy or (3) Monoclonal gammopathy of renal significance (MGRS) is a heterogeneous group of disorders characterized by renal involvement with paraproteins that are no longer MGUS but also do not meet criteria for the malignant haematological conditions of MM or Waldenström's macroglobulinemia. 

 

International Myeloma Working Group (IMWG) recommends serum and urine electrophoresis of high resolution for all patients suspected of having a plasma cell dyscrasia. This applies most commonly to clinical disorders that suggest multiple myeloma, Waldenström’s macroglobulinemia, or amyloidosis (AL), but also includes less frequent conditions, such as solitary plasmacytoma, POEMS syndrome, heavy-chain diseases, and immunoglobulin deposition disease. 

 

CELL® Serum protein electrophoresis kit is an inexpensive, easy-to-perform screening procedure for initial identification of monoclonal bands based on their physical properties. Separation of serum proteins are carried out in an alkaline buffer. The migrated (separated) proteins are then fixed and stained with Ponceu S red before densitometry reading. Monoclonal bands are usually seen in the ? zone but may be seen in proximity of the ? band or, rarely, in the ?2 region.

 

CELL® presents sPEP kits for both;

  •         MiniLite / Giant IFE instruments.
  •         Genio instruments

Features

 

  • CAE for serum protein separation.
  • AMR = between 4.4 and 8 g/dL.
  • High relsolution and good descrimination betwen bands.
  • Accuracy for the electrophoretic fractions:
    • CV for Albumin, alpha 2, beta and gamma fraction: ? 5%
    • CV for alpha 1: ? 10%
  • Analytical sensitivity: 0.03 g/dL (of monoclonal band detected in the gamma zone.
  • CE marked.

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