Aldolase
Product Description
UV | Kinetic
Available Options:
| REF | Volume |
|---|---|
Aldolase is a glycolytic enzyme that catalyzes the conversion of fructose 1-6-diphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate via the glycolysis metabolic pathway. There exists three cytosolicisoenzymes: aldolase A, which predominates in muscle; aldolase B, in the liver; and aldolase C, in the brain, of which the muscle type aldose A is found bound to the actin-containing filament of cytoskeleton. Within the cell, aldolase is localized in both the cytoplasm and nucleus. The enzyme regulates cell contraction through its reversible binding to these filaments.
Aldolase is likely ubiquitous to all cells, with larger concentrations present in muscle, liver, and brain tissues. The determination of Aldolase in serum have been of great interest in musculoskeletal problems. High increases of this enzyme occur in case of Duchenne muscular dystrophy. Smaller increases were found in cases of dermatomyositis and polymyositis. The aldolase blood test may be ordered to diagnose and monitor certain conditions related to skeletal muscle. It largely has been replaced by other muscle enzyme tests, especially CK (creatine kinase). However, a minority of people with muscle pain may have an elevated aldolase level even though their creatine kinase is normal. Therefore, the test may sometimes be requested by rheumatologists in addition to creatine kinase.
Product Features:
- UV, Kinetic assay.
- 15 days working reagent stability of R1 at 2-8
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