Lactate dehydrogenase (LDH)
Product Description
Pyruvate -> Lactate | SFBC)
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LDH is an intracellular enzyme which is widely distributed throughout the body and is found at high levels in tissues that utilize glucose for energy; it is therefore not organ specific. Structurally, the enzyme is a tetramer with the two most common protein subunits LDH-M (M=muscle) and LDH-H (H=heart), in different combinations forming five isoenzymes: H4, M4, and the three mixed tetramers (H3M1, H2M2, H1M3). Though the isoforms are enzymatically similar in function, their distribution varies with different tissues:
LDH-1 (H4) is found in the heart and in RBC (red blood cells), as well as the brain.
LDH-2 (H3M1) is in the reticulo-endothelial system.
LDH-3 (H2M2) is found in the lungs.
LDH-4 (H1M3) is found in the kidneys, placenta, and pancreas.
LDH-5 (M4) is found in the liver and striated muscle, also present in the brain.
LDH catalyzes the conversion of pyruvate to lactate with the regeneration of NADH to NAD+. This conversion is essential in hypoxic and anaerobic conditions when ATP production by oxidative phosphorylation is disrupted. As a consequence, LDH activity is up regulated in those conditions. Since the enzyme is widely distributed, an increase in LDH can reflect damage to a number of different tissues but not one in specific unless isozymes were quantified. LDH levels may be increased whenever there is cell necrosis or when neoplastic proliferation of cells causes an increase LDH production.
Product Features:
- Pyruvate to lactate conversion.
- Standardized protocol by the French Society of Clinical Biology (SFBC)
- Ready to use reagents.
- Kinetic rate, UV method.
- Wide AMR: ranging between 50 and 2000 iU/L.
- Programmable on most of the fully automated biochemistry analyzers
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