Complement C3

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Complement C3

Product Description

Immunoturbidimetry assay

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The complement system is a part of the innate immune system that enhances the ability of antibodies and phagocytes to clear microbes and damaged cells from an organism, promote inflammation, and attack the pathogen's cell membrane. The complement system consists of more than 30 proteins that are either present as soluble proteins in the blood or are present as membrane-associated proteins. Most of  the proteins and glycoproteins that constitute the complement system are synthesized by hepatocytes and also a substantial amounts by tissue macrophages, blood monocytes, and epithelial cells of the genitourinary system and gastrointestinal tract. Activation of complement leads to a sequential cascade of enzymatic reactions; the complement activation pathways, resulting in the formation of the potent anaphylatoxins C3a and C5a that elicit a plethora of physiological responses that range from chemo-attraction to apoptosis.

 

Complement activation is known to occur through three different pathways: alternate, classical and lectin involving proteins that mostly exist as inactive zymogens that are then sequentially cleaved and activated. All the pathways converge at C3; the most abundant complement protein found in the blood, resulting in the formation of the activation products, C3a, C3b, C5a and the membrane attack complex (C5b-9).

 

Complement C3 is the functional link between classical and alternative pathways of activation and it is the most concentrate component of the complement system in human plasma. Hepatic cells synthesize C3, although bacterial endotoxins induce synthesis by monocytes and fibroblasts. Concentration C3 increases as a consequence of an acute-phase response (trauma, surgery or inflammatory process), biliary obstruction and focal glomerulosclerosis. Decreasing C3 levels are consequence of a genetic deficiency that may increase the risk of infections particularly with encapsulated bacteria, or acquired deficiency that causes vascular disorders and severe infections.


Product features.

  • Intended for the quantitative estimation of Complement C3 in serum or plasma.
  • Immunoturbidimetry assay.
  • Suitable for use on of semiautomatic analyzers.
  • Can be programmed on fully automated instruments – subject to analyser model.
  • Ready to use reagents.
  • 6 points calibration.
  • Optional calibrator with values traceable to CRM 470/RPPHS (IRMM).
  • 30 days calibration stability. The calibration stability duration may highly vary and is subjected to the working environment.
  • AMR up to 600mg/dL.
  • LOQ =1 mg/dL.
  • No prozone effect up to 1500mg/dL.
  • CE marked.

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