Product Description

3,5-DiBr-PAESA | Colorimetric

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Most of the copper in blood plasma is bound to ceruloplasmin, approximately 15% to albumin, 10% to transcuprein and small amounts to small peptides and amino acids. Therefore, transcuprein and albumin represent the bulk of the exchangeable copper pool in plasma. The non-ceruloplasmin-bound copper (or so-called “free copper”) is toxic in Wilson Disease, leading to extrahepatic involvement and possibly exacerbating hepatic involvement.



Total Serum or plasma copper and ceruloplasmin are both widely utilized as biomarkers of the copper status. Their validity, however, may not as reliable as originally ascertained. Although they are decreased in the presence of severe copper deficiency, their concentrations may vary in the cases of mild deficiency. Furthermore, both demonstrate variability in their circulating concentrations related to age, sex, and pregnancy, and are increased by conditions such as inflammatory or infectious processes, cancer, and estrogen therapy which can hide copper deficiency. The increased concentrations of copper in serum is found in various liver diseases, carcinomas, acute and chronic infections, rheumatoid arthritis. Other conditions may be related to the increased synthesis of ceruloplasmin as an acute-phase reactant , and thus not to copper status as such. 

Product features.


  • Colorimetric – end point method.
  • Manual procedure for semiautomatic instrument users.
  • Inclusive of standard in the kit.
  • The value of the standard is traceable to NIST reference standard.
  • R1 working reagent stability = 15 days at 2-8°C.
  • R2 has an open vial stability of 90 days at 2-8°C.
  • Measurable at wavelengths between 570nm and 590nm.
  • Very wide AMR =3?g ~500 ?g/dL.
  • CE marked.



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