Procalcitonin
Product Description
Latex enhanced immunoturbidimetry assay.
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Procalcitonin (PCT) is a peptide precursor of the hormone calcitonin, secreted in regulated fashion to reduce serum calcium concentration in order to maintain calcium homeostasis. Under normal physiological conditions, PCT is produced mainly by thyroidal c-cells and in small amounts in neuroendocrine cells of lung and small intestine respectively. Here it is further processed into its effective hormone calcitonin and stored in cellular vesicles until released in conditions of high serum Ca level. Calcitonin decrease the calcium absorption by inhibiting activity of osteoclasts, which are responsible for breaking down bone; thus proper serum levels of calcium is maintatined in the circulation. Hence, PCT is nearly not detectable in serum of normo-calcaemic patients.
The level of PCT increases in response to any shock like state, trauma, surgery and pro-inflammatory stimuli especially of bacterial origin making it as an acute phase reactant. Generally, viral infections are characterized by IFN-? activation, attenuate the PCT production. On the other hand, the high PCT levels produced during bacterial infections are not followed by a parallel increase in calcitonin or serum calcium levels. Because of these characteristics of PCT, it has been used as a specific serum biomarker in differentiating bacterial and nonbacterial etiology.
PCT levels are raised much earlier during an infectious process in comparison with CRP (4
Product features:
- Immunoturbidimetric method.
- Ready to use reagent.
- Programmable on most of the fully automated analyzers.
- Good correlation with other commercial kits.
- AMR = 0.2 ~ 52ng/mL.
- 6 points calibration.
- Average on-board stability of 30 days (on selected instruments).*
- Calibration stability of 14 days (on selected instruments at controlled environment.)*
- Calibrators and controls are not included.**
* May vary from user to user or ambience.
**Should be purchased.
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