AST - (Aspartate aminotransferase) (Labkit)

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AST - (Aspartate aminotransferase) (Labkit)

Product Description

IFCC | Kinetic UV

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Aspartate transaminase (AST), which is also referred to as aspartate aminotransferase or serum glutamic-oxaloacetic transaminase (SGOT) in other literatures, catalyses the reversible transfer of amino group between aspartate and glutamate. Like ALT, AST is found in the cytoplasm of hepatocytes and other tissues, including skeletal muscle. Injury to hepatocytes causes leakage of AST into the extracellular compartment with subsequent elevation in serum AST activity. Since it is more widespread than ALT, elevated AST may be indicative of heart, pancreas, anaemia, kidney, and musculoskeletal pathologies and is usually associated with other tests to support a diagnosis.

 

AST activity may also be elevated in times of skeletal muscle injury in preclinical species. The magnitude of AST elevation is usually lesser than ALT when both are elevated due to hepatocellular injury; because of the longer half-life of ALT and the greater fraction of AST that is bound to the mitochondria. The practice of considering a high ratio of AST/ALT to be more indicative of skeletal muscle injury has been suggested and may aid in distinguishing muscle versus liver injury. 

Product Features:

  • IFCC - Liquid reagents without pyridoxal 5’ phosphate.
  • Both ready to use reagents as well as lyophilized reagents for different customers’ choice.
  • Programmable on most of the fully automated biochemistry analyzers.
  • Longer working reagent stability ? 21 days at 2-8°C. / 72 hours at R.T, making it ideal for semiautomatic instrument users.
  • Longer working reagent stability ? 21 days at 2-8°C. / 4 days at R.T, making it more suitable for semiautomatic instrument users with very less workload (prdt. code 30240,41 and 42)
  • AMR = 0~360 iU/L.
  • No significant interference with other serum analytes.
  • First party controls and calibrators are available on additional cost.

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