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Cholesterol is the precursor of all steroid hormones, cholesterol esters, and bile acids, and is a component of the plasma membrane of cells. Total cholesterol consists of free cholesterol and cholesterol esters. Serum cholesterol is derived from the diet and is synthesized in the liver. Low-density lipoproteins (LDLs) consist mostly of protein, are rich in cholesterol, and are derived from the breakdown of very low-density lipoproteins (VLDLs). High-density lipoproteins (HDLs), the smallest particles, consist mostly of cholesterol, protein, and phospholipids, with only a small quantity of triglycerides. LDLs are a source of cholesterol for peripheral cells, such as the adrenal gland; HDLs transport cholesterol from peripheral cells back to the liver. LDLs and HDLs do no contribute to visible lipaemia. Excess cholesterol is excreted via the bile, where it is esterified. Cholesterol measurements can provide supportive evidence in some diseases.

Blood cholesterol level is affected by a number of factors, including genetics, diet, and tobacco usage, level of physical activity, age, and menopause. Quantification of total cholesterol allows the detection of hypercholesterolemia, isolated or associated with hypertriglyceridemia. High cholesterol concentrations are associated with a high risk for vascular accident and apparition of atherosclerosis. The LDL/HDL ratio should be taken in consideration for evaluating the risk of developing cardiovascular diseases.

Product Features:

  • Enzymatic-colorimetric



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